Antipsychotic drugs
Traditional, e.g., haloperidol, thorazine:
Mechanism of action: D2 receptor blockade
Indications: target psychotic symptoms and delirium
Side effects:
Location: nigrostriatal dopaminergic (basal ganglia) blockade
Clinical presentation: stiffness, muscles spasm, poor coordination/initiation of movement
Tardive dyskinesia: abnormal, involuntary movements associated with chronic antipsychotic treatment, especially higher potency agents
Neuroleptic Malingnant Syndrome:
Sexual side effects:
Global cognitive slowing:
Pituitary -> hyperprolactinemia via dopamine blockade in tuberoinfundibular system -> galactorrhea or gynecomastia
Area postrema -> antiemetic
Frontal cortex, temporal lobe, limbic system -> ? antipsychotic effect