Name:

Generic:

Dose (mg):

Mechanism:

Comments

Abilify

Aripiprazole

10, 15, 20, 30

Partial D2, 5HT1A agonist/ 5HT2A antagonist

Less sedation than other agents

Geodon

ziprasidone

20 bid - 100 bid

Rare ECG changes - avoid if recent heart attack

Risperdal

Risperidone

2 bid - 6 bid max

5HT-2 and D2 receptor blockade

? EPS, orthostatic hypotension, weight gain (less so than Zyprexa, more than placebo)

Seroquel

Quetiapine

600-800 mg

sedation, dizziness, dry mouth, constipation; intermediate weight gain risk

Zyprexa (also available as Zydis)

Olanzapine

10-20 qhs

5HT2A antag, D2 antag; selectively inhibits dopamine tracts in the mesolimbic pathways

Weight gain (median 14#) is a major problem; diabetes risk is elevated; extremely sedating. Very effective at both mood stabilization and anti-psychosis.

Clozaril

Clozapine

Chemically similar to olanzapine; antagonist of 5HT2 receptor (serotonin)

Bone marrow suppression a rare but potentially fatal side effect, so weekly blood monitoring required; diabetes risk